These treatment advances have greatly expanded the treatment landscape. Tumor histology remains a critical factor in decision-making biomarker testing for HER2 is performed only on adenocarcinomas, whereas drug selection for a given line of therapy for squamous cell carcinoma and adenocarcinoma may differ based on PD-L1 expression levels, she said. Because these malignancies are now being categorized according to HER2 status, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) status, and PD-L1 expression, biomarker testing is a necessary first step at diagnosis to facilitate treatment management across the therapy continuum. Matkowskyj, MD, PhD, Associate Professor in the Department of Pathology and Laboratory Medicine and Director of the UW Carbone Cancer Center Translational Sciences BioCore. Lurie Comprehensive Cancer Center of Northwestern University, at the NCCN 2021 Virtual Annual Conference.įurthermore, the growing importance of biomarkers in these cancers was emphasized by Kristina A. Mulcahy, MD, Professor, Department of Hematology-Oncology, Northwestern University, and Director, Gastrointestinal Oncology Program, Robert H. Denlinger, MD, Chief, Division of Gastrointestinal Medical Oncology, and Co-Director, Survivorship Program, and Associate Professor, Department of Hematology-Oncology, Fox Chase Cancer Center, and Mary F. Trials supporting the use of these improved therapies, and their application in the clinic for certain subgroups, was presented by Crystal S. These new drugs include immune checkpoint inhibitors (ICIs), the HER2-directed agent trastuzumab-deruxtecan (T-DXd), the monoclonal antibody ramucirumab, and the cytotoxic agent trifluridine/tipiracil. ICIs are now moving into the adjuvant setting as well, and a new recommendation is nivolumab use after preoperative chemoradiation and surgery in patients who have residual disease identified at the time of their R0 resections.įor the treatment of gastric and esophageal cancers, recent studies have demonstrated robust findings for new drugs that, as a consequence, are becoming FDA-approved and added to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Esophageal and Esophagogastric Junction Cancers and for Gastric Cancer. T-DXd is another new second-line option for HER2-positive esophageal, GEJ, and gastric adenocarcinomas. Recently, ICIs have been incorporated into the first-line treatment of HER2-negative advanced esophageal, gastroesophageal junction (GEJ), and gastric cancers, in addition to second-line treatment of advanced esophageal and GEJ cancer of squamous histology. These agents convey varying degrees of benefit depending on treatment line, PD-L1 expression, HER2 expression, and tumor histology. In addition to pembrolizumab and nivolumab, new treatment options include trastuzumab-deruxtecan (T-DXd), ramucirumab, and trifluridine/tipiracil. For the treatment of gastric and esophageal cancers, several pivotal trials-especially those evaluating immune checkpoint inhibitors (ICIs)-have altered the treatment landscape and led to changes in the NCCN Guidelines.
0 Comments
Wacom (under Mapping) and Huion have this option, I don’t know about others.Īlso turn off other tablet services built into Windows or your tablet software, such as Pen Flicks (the Pen and Touch applet in the Control Panel) or long-press or press-and-hold or hard-press for right-click (try the Pen and Touch applet in the Control Panel and/or your pen settings control applet, which might be in Control Panel, or in the system tray in the right lower corner, or maybe in the start menu). If your tablet software allows it, and if you are using Windows (I don’t know whether Macs have any equivalent), turn off Windows Ink/TabletPC services. It might have some sense of purpose on a Microsoft Surface device that has no keyboard attached. On any other notebook or desktop computer the Windows Ink feature is absolute garbage. Next, try File menu, Environment Setting, and change Brush Coordinate from Use Tablet Coordinate to Use Mouse Coordinate. 0 Comments Its a really annoying thing that gets in the way. The first thing to try is the latest tablet driver from your tablet manufacturer (and restart your computer after installing it). A lot of graphics programs have changed to using this second system, but FireAlpaca is keeping the Wintab system for backwards compatibility. There are two pressure/location pane/tablet systems in Windows, the older Wintab system which is provided by the tablet manufacturer (quality varies considerably) which is used by FireAlpaca (and a few other programs) and is compatible back to Windows XP, and the Microsoft Ink/TabletPC system, which really only works well on Windows 7 onwards (there were some versions for earlier Windows, but they were fairly clunky), is built into Windows and is a lot more system-compatible with tablets (especially cheaper tablets). The logs revealed how, within a few seconds, the same VPN IP address had logged into Lin’s real Gmail address, another Gmail address used for some threats, and a account Lin created. The question here is how the FBI was working with PureVPN to get these details. The documents from the court indicated that logs provided by PureVPN helped the FBI in prosecution. The security audit was the result of a court case where a person from Massachusetts was arrested on charges of cyberstalking, against a female roommate and her friends and family members. To celebrate the successful audit, PureVPN also offered new users 30% off on any of their plans by using the code ‘’NOLOGVPN’’. They stated that they didn’t find any evidence of system configurations or service log files that either independently or collectively lead to recognizing a specific person or their activity while they’re using the PureVPN service. After completing the inspection, Altius IT also provided the conclusion to clear the customer’s doubts. To verify its claim, the company decides to hire Altius IT to perform an audit of its security systems and privacy policies. The VPN service provider, after updating their privacy policy to become a zero-log VPN, it received tons of emails, feedback, queries, and support tickets from its customers regarding its internal logging policies. These service providers keep no records of users’ online activities and ensure their online privacy. After this testing, they officially gave PureVPN a clean chit on their no-logs claims.Īpart from PureVPN, several other VPN providers, such as ExpressVPN and NordVPN, have no-log policies. The audit company also tested purevpn’s system log files, network infrastructure documents, and system configurations. The famous security audit company, Altius IT, examined Purevpn logs regarding browser history, connection logs, DNS queries, outgoing traffic, user’s originating IP address, and assigned VPN IP address. It has proven its no-logs claim as a part of its commitment to delivering robust privacy and security to its customers all around the globe. PureVPN recently joined the list of top VPNs. It is because the providers are looking to legitimize their claims, and PureVPN is the latest company that had to undergo an independent audit. Now audits are becoming a trend in the VPN industry. “We’re so excited that local knowledge, national expertise, and a whole lot of persistence came together to secure this win for climbing in southern Nevada.” “When sustainable climbing access is threatened, local climbers are the first and best line of defense,” says Bryan Freisen, president of SNCC. And it secures after-hours access in the event of future fees and reservation requirements, subject to site-specific environmental review. If fees are implemented, it proactively addresses the issue of reservation systems and provides climbers with avenues for collaboration and input. The settlement mandates a new round of environmental review and ensures another decision point before any fee or reservation system is implemented for Calico Basin. We’re thrilled to secure this victory for the local community.” “Sustainable recreation access to places like Calico Basin is good for our health and it’s good for our environment-connecting more people to nature and inspiring them to protect and conserve the lands they love. “This agreement is a win for climbers, conservationists, and anyone who recreates in Calico Basin,” says Access Fund Executive Director Chris Winter. It marks the successful resolution of an administrative appeal Access Fund and SNCC filed in June, 2022. The agreement ensures that BLM will consider the full range of potential impacts to the area and recreational uses before making a final management decision. Agreement Protects Sustainable and Equitable Access ConservationĬlimbers will soon have a voice in the plans to manage the Red Rock National Conservation Area, thanks to a newly announced settlement agreement between Access Fund, the Southern Nevada Climbers Coalition (SNCC), and the Bureau of Land Management (BLM). We’re a social media-obsessed culture, so it’s no surprise that we want to scroll through countless images of dogs snoozing, napping, and lounging. There are countless ways to entertain yourself in Hong Kong's diverse districts. Sleeping Dog Images: 26 of the Cutest Pics by Carol Bryant i Published on Sleeping dog images are some of the most popular and highly searched-for photos on the internet. Sort by: Most popular Cat and dog sleeping. Sleeping dogs PNG Images, Bungo Stray Dogs, Sleeping Beauty, Dogs Of War, Dogs And Cats, Watch Dogs Aiden Pearce, Isle Of Dogs, Watch Dogs 2 Transparent. Hong Kong is your ultimate playground: Enter illegal street races, gamble on cock fights, or kick back with some karaoke. Sleeping Dogs Photos Pictures, Images and Stock Photos View sleeping dogs photos videos Browse 69,100+ sleeping dogs photos stock photos and images available, or start a new search to explore more stock photos and images. Epic high-speed thrills: Burn up the streets or tear up the sea in a vast array of exotic cars, superbikes and speedboats. Explosive action fuelled by a seamless mix of deadly martial arts, intense gunfights and brutal takedowns. A mature, gritty undercover cop drama where a wrong decision can blow your cover at any time. FEATURES: -With all previously available content included and a wealth of new improvements, Hong Kong has never felt so alive. Thousands of new images every day Completely Free to Use High-quality videos and images from Pexels. The 40 Cutest Sleeping Dogs in the World: A full color picture book for Seniors with Alzheimers or Dementia (The 40 Most Beautiful Series of Picture Books). Sleeping Dogs Hong Kong is the ultimate playground. Download and use 20,000+ Dog stock photos for free. Dominate Hong Kongs buzzing streets in thrilling illegal street races and tear it up in explosive firearms action. Destroy your opponents in brutal hand-to-hand combat using an unmatched martial arts system. You'll have to prove yourself worthy as you fight your way up the organization, taking part in brutal criminal activities without blowing your cover. Play as Wei Shen - the highly skilled undercover cop trying to take down the Triads from the inside out. A vibrant, neon city teaming with life, Hong Kongs exotic locations and busy streets and markets hide one of the most powerful and dangerous criminal organizations in the world: the notorious Triads. Alongside a wealth of new technological, audio and visual improvements, Hong Kong has never felt so alive. All 24 previously available DLC extensions from the Xbox 360 version have been integrated into the game, including the story-extending episode Year of the Snake and the horror-themed Nightmare in North Point. All 24 previously available DLC extensions from the Xbox 360 version have been integrated into the game, including the story-extending episode Year The Definitive Edition of the critically acclaimed, award winning open-world action adventure, reworked, rebuilt and re-mastered for Xbox One. Summary: The Definitive Edition of the critically acclaimed, award winning open-world action adventure, reworked, rebuilt and re-mastered for Xbox One. More importantly, Filmora is totally free to try. This release of Zwei-Stein (ZS) was designed as a complex utility for editing and compositing. A user-friendly interface and low learning curve would help a lot for beginners to edit videos. Download ZS4 Video Editor 3.01 full version. However, this software is lacking maintenance for long, not recommended in 2021.įilmora, with its powerful features and frequent updates, can handle basically all video formats that you'll see every day while editing video. Users can customize the width and height of the output video, add unlimited tracks and sub-composites, slave effects and change, compose controls to audio waveforms, and more. ZS4 Video Editor is another free video editing tool with over 150 built-in video effects including excellent color and chroma keying. Some of its outstanding features include video capture and import, GPU- accelerated real-time effects, color correction, autosave and media management, etc. It supports a wide range of video formats like AVI, MOV, MPG, and more. Download tb ZS4 Video Editor 0. Lightworks is a free video editor but can handle most of what you’d expect from a professional video editing application. Reminder: while installing, it will write some preferences to the Registry. With it, you can adjust the frame rate, remove audio tracks, resize, rotate, flip, adjust the brightness and contrast, and more. ZS4 runs on Windows, Linux and OSX and is free to download and use. It’s geared towards processing AVI files and able to do a variety of pre and post-processing operations on your video. ZS4 Video Editor, the new incarnation of Zwei-Stein Video Editor, is advanced video editing and compositing software with over 150 built-in video effects. Virtualdub is a well-known video editing tool that allows you to capture video and perform video editing. Although this may sound overly simple, it’s actually robust enough to ensure that your videos look professional. With it, you can easily splice video clips or add filters. ZS4 includes excellent operations for color correction, image adjustments, distortion effects, video size modification, speed control etc. It supports various video formats such as AVI, MPEG, MP4, and ASF. What’s more, you can even modify the existing effects if you have knowledge about using XML code.Īvidemux is a basic yet very capable video editing program. It contains features like drag-n-drop functionality, transitions, titles, credits, timeline narration, and more. It’s able to handle the least video formats: asf, avi. ZS4 is video editing and compositing software which aims to provide media experts with a facility to combine a variety of media types. This program can also act as a video montage maker.Windows Movie Maker is a great free video editing tool for Windows users. It's easy to use and fast too, able to create finished videos in a matter of minutes and making the entire video-editing process fun for all. Movavi Video Editor has a free trial so you can try it for free or pay a fee to get lifetime access to this advanced video editor and all of its features. Really easy to use and with lots of great editing features, it's perfect for beginners and advanced users alike who want to trim, cut, join, and enhance their clips with countless effects like titles, filters, transitions, and chroma key. Our special pick for this guide is Movavi Video Editor. There are unlimited features of video editing when you enter the ZS4 ecosystem. The best part of the software is that it is accessible to both Windows and Mac users. Price: 7-day trial period with a watermark added to videos, $21.95 for the full versionīest for: Users who want to be able to edit and adjust videos with ease ZS4 is a revival of the aforementioned software, making it a free chroma key software along with advanced video editing functionality. If you don’t want to use desktop screen reader software, then you can also use this Screen Reader Chrome extension by Google. Just download and install the software and follow the below instruction to use it with Google Docs. There are no special settings to configure to use it with Google Docs. It’s a free open source screen reader software that is small in size and very easy to use. If not, then I will recommend you use the NVDA screen reader software. You don’t need to go through this step if you already have a screen reader software built-in, like Apple VoiceOver or ChromeVox. Use Google Docs Screen Reader to read text aloudīefore you use Google Docs screen reader options, you need to get a dedicated screen reader software that will read aloud the text in a Google Docs document. If that doesn’t work, copy-paste text manually into a new Google doc instead.Also read: 2 Ways To Add Captions To Images in Google Docs 1. If you’re unable to convert your document, try one of these options: open it in Word and then save it as PDF use the OCR option when converting from PDF to Google Docs. Just double-click on the file and open it as a Google Doc. Google Drive allows you to convert PDFs to Google Docs by simply dragging and dropping them into your Google Drive. How do I save a PDF file as a Google Doc? To save the document on iOS, choose a recipient or click Save to Files.Click Send a Copy, choose PDF, then confirm by clicking the OK button.Click on the three dots at the top-right of your tablet or phone.Open your document by tapping the Google Docs app.How do I email a Google Doc as a PDF to an iOS device? Tap the Download icon next to the three dots to save the PDF. Select a recipient, and then hit send.Click the Save button to save this article. If you prefer to save the article, click on the Save button.Tap the three dots at the top-right corner.You can find PDF in the dropdown menu if you don’t see it.Īdditional Reading: Top 10 Google Docs Add-Ons How do I email a Google Doc as a PDF to an Android device?.Enter the recipient’s e-mail address, as well as subject and body text.Click on the mail icon to select Email this File.Open your Google Doc, and click on File.How do I email a Google Doc in PDF format to my friend? Click Save to Google Drive when you have selected Destination.Click on File in the toolbar, and then select Print from the drop down menu.Only Google Chrome can save PDFs to Google Drive. Click on the Download tab and choose PDF Document (.pdf).Ī PDF will open automatically in your browser when you download it. To quickly find and edit the PDFs, you can click on the name of each document.Click the “File” tab at the top right of your screen.This makes Google Docs a great tool for collaboration with writers who are always updating their drafts. It is important to not make a document public in order to work together. Google Docs’ PDF feature allows you to edit your document without worrying about file sizes or other people editing it behind your back. Step 3: You can share your PDF files with both Android and iOS devices. Step 2: Send your document to us as a PDF attachment. Step 1: Click the File menu in Google Docs to save a Google Doc as a PDF. * SUPERCHARGE Your Gmail account with this FREE chrome extension *** How do I save a Google Doc to a PDF? Wondering how to save a Google Doc as a PDF? Here are three ways to do it on PC or Mac. It turns out that it isn’t as hard to convert a Google Doc into a PDF if you know how. This process doesn’t require any downloading! People share documents constantly in chat apps such as Slack or via email. Google Docs has become a more important part of the workplace as more people work remotely. This cookie is set by GDPR Cookie Consent plugin. These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. Analysis of the Roman aureus shows the purity level usually to have been near to 24 karat gold, so in excess of 99% pure. However, regardless of the size or weight of the aureus, the coin’s purity was little affected. What was the purity of the Roman Aureus coin? aureus will heal without medical treatment. For those people who do get an infection, the time from exposure to development of disease can be from days to years. How long does it take for S.aureus to heal?ĭuration of illness. Two of the most expensive aurei were sold in the same auction in 2008. 98–117) sold for $15,000, and a silver coin of the same emperor sold for $100. For instance, in one auction, an aureus of Trajan (r. Which is more expensive an aureus or a denarius?Īn aureus is usually much more expensive than a denarius issued by the same emperor. Token coinage consisted henceforth of brass sesterces and dupondii (equal to four…. …based the coinage on the aureus of 142 of a pound of gold, equivalent to 25 denarii, each of 184 of a pound of silver, the metals being struck almost pure. Rosenbach (1842-1923), a German surgeon, isolated two strains of staphylococci, which he named for the pigmented appearance of their colonies: Staphylococcus aureus, from the Latin aurum for gold, and Staphylococcus albus (now called epidermidis), from the Latin albus for white (5). But “bullion equivalent value” of ancient coins is a very shaky basis for comparing buying power across the centuries. (In 89 bc, the sestertius, equal to one-quarter of a denarius, replaced the bronze ass as a unit of account.)īullion Equivalent Value An 8.18-gram Roman gold aureus from the time of Julius Caesar (died 44 BCE) would contain gold worth $330.50. It was first named nummus aureus (“gold money”), or denarius aureus, and was equal to 25 silver denarii a denarius equaled 10 bronze asses. NameĪureus, basic gold monetary unit of ancient Rome and the Roman world. In 301, one gold aureus was worth 833⅓ denarii by 324, the same aureus was worth 4,350 denarii….Gold content and price comparison. 4 Which is more expensive an aureus or a denarius?.3 How much was a pound of aureus worth?. Instead, you can update the Site Settings in Google Chrome so that PDFs are. If that doesn't work and you need to install a new version of the free Acrobat Reader, you’ll need to uninstall any older version(s) before installing the new version of Acrobat Reader. Google Chrome no longer supports Adobe Acrobat for reading PDFs in the browser. Ensure that Adobe Acrobat reader is installed on your machine and up to date. You may be able to open a downloaded PDF document in Acrobat by just double-clicking it after you download it to your desktop. To Set Adobe Reader as Default in Google Chrome. When Acrobat Reader is open, go to File, then to Open, then to where you saved the document.You may want to make a note of where you saved it by default, it will be downloaded to the Downloads folder. Select “Save Target As” or “Save Link As.” Both Firefox and Chromium, the open source version of Googles Chrome browser, come bundled with in-browser PDF readers, so an external plugin is no longer.Right-click on the link to the document.To download PDF documents from this website: To obtain the latest version of the free Adobe Acrobat Reader, please visit the Adobe Web site. Download PDF Reader from the Google Play Store PDF Reader is readily available on the Google. While the recommended web browsers (Chrome, Edge, Safari and Firefox) have their own PDF viewers that allow you to view and print forms, instruction files, and other PDF files found throughout this site, fillable forms (especially those with 2D Barcodes) require Adobe Acrobat (Pro or Reader) in order for you to fill out and complete them successfully. pdfFiller extension, the feature-rich Chrome PDF editor. How to install Adobe Acrobat Reader on a Chromebook and add access to Google Drive EVSC ICATS 866 subscribers Subscribe 21K views 2 years ago This video is for EVSC students who are using. Adobe Acrobat Reader - Requirements and Download Information And they have spread their wings even more with the availability on cell phones.Looking for a way to Download Super Contraption Maker for Windows 10/8/7 PC? You are in the correct place then. It enhances your creative skills and provide lots of entertainment.ĭigital Games have taken the learning to a new level with challenging problems and real life game-play. New constructions can be made by putting the blocks together. Its a sandbox game where a player can play a human made of cubes which can walk around and break the blocks which make up the landscape. You can start either from a blank map or a pre-designed level, always have the tools to customize the topography, add plant and animal life, and program behaviours for specific objects. With the set of creation tools you can make your own video games, movies and create other experiences. Unleash the gaming creator inside you with this amazing, interactive and creative “game maker” video game. So buckle up your imaginative skills and ride your creativity on the roller coaster to become a tycoon. There is no limit to what you can create with well designed game-play mechanics, appealing graphics, and really high re-playability value. Become a Roller Coaster Tycoon by building the most thrilling roller coaster the world has ever seen. It teaches money management and economics. You can create your own original objects, assign unique properties and share them with friends. Create and modify objects to solve puzzles. Venture into a wide-open world where the most powerful tool is your imagination. ScribblenautsĬreate anything and edit anything. Algodoo’s is a great game to learn physics practically. It also allows you to play with the gravitation, friction, acceleration, and other principles of physics. AlgodooĪlgodoo is a toolbox game with physics simulations in which everything you create using the tools like polygons, cut, brush, box, circle, gear, plane, chain, spring, fixate, hinge, tracer and laser pen can come to life with a few clicks and drags. These training missions are math games that involve performing equations to win. Its a role playing game in which you have to go through various missions so you can learn how to save the universe from bad guys. Math BlasterĪmazing game for children to learn math. You need to solve the series of puzzles by tele-porting the character and a simple object using “the Aperture Science Hand-held Portal Device”. It teaches spatial reasoning, engineering, and even mathematics. PortalĪ rare game that can change our thinking about the world, and how we view the physical space around us. There are two modes to enjoy: creative and survival. Space Engineersīuild space structures, plan energy sources, make space crafts, float around in space, design space crafts, scavenge for resources etc., Space engineers involves construction, engineering and maintenance of space works. The players need to build space worthy crafts to fly its crew out of space without killing them. Good for learning about orbital flight mechanics, Kerbal Space program is a multi-genre game where space programs are created by players. Puzzles can be solved by chain reactions full of hamster motors, trampolines, alligators, cats and more. Contraption MakerĬontraption Maker is a game featuring a robust physics engine with which you can solve puzzles or make your own crazy contraptions. Here is the list of well designed video games to give a workout to your creative, imaginative and critical thinking skills. “Well-designed video games can enhance problem-solving skills and make learning more effective” Steven Solata an Education Psychologist |